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<pubDate>Wed, 13 May 2026 01:15:15 GMT</pubDate>
<dc:date>2026-05-13T01:15:15Z</dc:date>
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<title>Scholarly literature</title>
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<title>In silico evaluation of macroalgae specific carbohydrates for antioxidant, anti-inflammatory and antiglycemic activity,Carbohydrate Research</title>
<link>http://drs.nio.res.in/drs/handle/2264/9654</link>
<description>In silico evaluation of macroalgae specific carbohydrates for antioxidant, anti-inflammatory and antiglycemic activity,Carbohydrate Research
Phakatkar, S.; Manohar, C.S.; Saravanan,S.; Nair,V.A.
Seaweeds represent a rich source of bioactive carbohydrates and complex polysaccharides with promising applications in managing oxidative stress, inflammation and glycemic control as a sustainable treatment of diabetes mellitus. This study employed an in silico approach to evaluate the therapeutic potential of all twelve major macroalgae specific carbohydrates. Disaccharide units of the macroalgal carbohydrate polymers were designed, energy-minimised, screened for drug-likeness and bioactivity in order to identify the shared targets for antioxidant, anti-inflammatory and antiglycemic activities with these ligands. The predicted protein targets were integrated with disease-associated genes and protein-protein interaction networks were constructed to validate and understand the metabolic functions. Drug-likeness and bioactivity indicated favourable pharmacokinetic and therapeutic properties. Enrichment analyses revealed that ligands modulate diverse biological processes linked to oxidative stress mitigation, inflammatory regulation and glucose metabolism. From the docked ligands, monomeric sugar ligands of ?1?6 laminarin and ulvan B exhibited the highest binding affinities with multiple key targets, followed by fucoidan, ulvan A, alginate and ?-, ?- and ?-carrageenans that showed substantial interactions. Notably, dihydrofolate reductase (DHFR), and Harvey rat sarcoma viral oncogene homolog (HRAS) were identified as promising targets for antiglycemic activity and glutathione reductase (GSR) were linked to both antioxidant and antiglycemic activities. Renin (REN) showed selective affinity with ?-carrageenan in the anti-inflammatory pathway and angiotensin converting enzyme (ACE) appeared as a common promiscuous target across all three activities. These findings highlight the potential of seaweed-derived sugars to modulate key regulatory proteins and signalling pathways, suggesting their promising role as natural, multi-functional therapeutic agents for managing oxidative, inflammatory and metabolic disorders.
IF2024= 2.5
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<pubDate>Thu, 01 Jan 2026 00:00:00 GMT</pubDate>
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<dc:date>2026-01-01T00:00:00Z</dc:date>
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<title>Characterization of pink pigmented lesions and its associated inflammatory-like responses that influence resilience in a scleractinian coral</title>
<link>http://drs.nio.res.in/drs/handle/2264/9653</link>
<description>Characterization of pink pigmented lesions and its associated inflammatory-like responses that influence resilience in a scleractinian coral
Lawrance I.; Ravindran, C.
The reef-building Scleractinian coral Porites lutea is widely affected by abnormal pink inflammations including Pink line syndrome (PLS) and Pink spot (PS). However, the immune responses of these non-normal pink pigmented tissue lesions in P. lutea are poorly understood. This study aimed to investigate the histopathological changes, innate immune responses, and microbial community shifts associated with pink-pigmented lesions in P. lutea in order to better understand disease severity and recovery. Healthy and pigmented tissues were analyzed using comparative histopathology, microscopy, enzymatic assays, protease profiling, and genome-level screening of microbial communities and functional response genes. Histopathology revealed fragmentation, degradation, and disintegration of the polyp gastrodermal architecture and mesoglea in pigmented tissues. Bacterial colonizers occurred in both healthy and pigmented tissues, whereas ciliates were detected only in the lesions. Pigmented tissues also showed reduced numbers and surface area of symbiotic algae, ova, and mesenterial filaments, indicating compromised survival and fecundity. Increased melanin deposition and mucus secretion, together with elevated phenol oxidase, peroxidase, superoxide dismutase, catalase, and protease activities, indicated strong innate immune and oxidative stress responses in inflamed tissues. Genome-level screening further revealed shifts in microbial communities and stress-related functions between healthy and pigmented tissues. These findings show that pink inflammatory lesions in P. lutea are associated with major tissue damage, immune activation, and microbial reorganization, and provide insight into the resilience of this massive coral under biotic and abiotic stress.
IF2024= 2.4
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<pubDate>Thu, 01 Jan 2026 00:00:00 GMT</pubDate>
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<dc:date>2026-01-01T00:00:00Z</dc:date>
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<title>Subsurface thermogenic methane source and impact on pore-fluid biogeochemistry in shallow shelf sediments off the West Coast of India</title>
<link>http://drs.nio.res.in/drs/handle/2264/9655</link>
<description>Subsurface thermogenic methane source and impact on pore-fluid biogeochemistry in shallow shelf sediments off the West Coast of India
Sivan, K.; Mazumdar, A.; Peketi, A.; Zatale, A.; Sadique, M.; Ghosh, A.; Pillutla, S.P. K.; Mathai, J.; Mishra, Shubhshree
A detailed geochemical investigation of a 5.25 m-long sediment core from the gas-rich shallow seasonally hypoxic shelf off the west coast of India (eastern Arabian Sea) provides the first robust geochemical evidence for deep-seated thermogenic methane (CH4) in this region. The $$\updelta^{13}{\text{C}_{{\text{CH}}_{4}}}$$values ( 113.6 to  30.5 ), isotopically enriched higher hydrocarbons (C2 C4), low C1/C2 ratios (&lt;70), together with down-core DIC concentrations and ?13CDIC values, collectively indicate a mixed biogenic thermogenic CH4 origin, coupled with significant biogeochemical transformation of gas compositions. The down-core DIC concentrations and ?13CDIC values confirm active hydrogenotrophic methanogenesis below the sulfate methane transition zone (SMTZ). The modified Bernard plot shows clustering of data points across the thermogenic biogenic CH4 mixing curve, suggesting a mixed gas origin as well as biogeochemical transformation of gas compositions, namely the preferential consumption of CH4, which leads to a significant decrease in ?13C values of residual CH4 and in the C1/C2 ratios. The biogeochemical transformation of gas compositions is attributed to sulfate-dependent anaerobic oxidation of methane (SO42  AOM), with additional possibilities involving Fe Mn-dependent AOM (Fe Mn AOM) below the SMTZ. The widespread occurrence of gas-charged sediments, coupled with the detection of thermogenic hydrocarbons, underscores the hydrocarbon potential of the western continental margin of India.
IF2024=1.7
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<pubDate>Thu, 01 Jan 2026 00:00:00 GMT</pubDate>
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<dc:date>2026-01-01T00:00:00Z</dc:date>
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<title>Response of larger mesozooplankton (&gt;?1 mm) to upwelling and river-induced stratification in the eastern Arabian Sea</title>
<link>http://drs.nio.res.in/drs/handle/2264/9657</link>
<description>Response of larger mesozooplankton (&gt;?1 mm) to upwelling and river-induced stratification in the eastern Arabian Sea
Sambath, K.R.; Karnan, C.; Olivia, N.F.J.; Sahu, B.K.
Coastal water stratification, controlled by riverine input and seasonal upwelling, strongly influences nutrient availability, oxygen dynamics, and zooplankton distribution in tropical shelf ecosystems. Despite its importance, the response of larger zooplankton (&gt;?1 mm) to these combined effects remains poorly understood in the eastern Arabian Sea. This study investigates these dynamics along the west coast of India (Goa and Kochi) during the southwest monsoon (SWM; September 2022). During the SWM of 2022 (June-September), rainfall was higher along the Goa coast (avg. 19? ?25 mm/day) than at Kochi (avg. 14? ?20 mm/day), with episodic events likely producing intermittent freshwater pulses into coastal waters. A freshwater lens (salinity?&lt;?32), approximately 2.64? ?0.4 m thick and extending over 11 km, formed a wedge-like stratification above upwelled, cooler, high-salinity, and oxygen-deficient waters off Goa. In contrast, the offshore expansion of this stratification was weaker in Kochi (avg. 2? ?0.6 m thick; horizontal span?~?5 km). The surface chlorophyll-a concentrations were higher and more widespread in Kochi, likely reflecting phytoplankton blooms, driven by stronger upwelling and weaker stratification. In Goa, larger zooplankton biovolume tended to increase toward offshore regions above weakly stratified waters, while in Kochi, high chlorophyll-a concentrations co-occurring with subsurface hypoxia corresponded with lower zooplankton abundance. Chaetognaths were the dominant group in both regions, with an average biovolume of 588? ?990 mm /m  in Goa and 2.1? ?1.8 mm /m  in Kochi during the sampling period. This study documents an offshore increase in the larger zooplankton along the central eastern Arabian Sea during the SWM, a pattern consistent with rainfall- and stratification-related habitat compression proposed previously for this region.
IF2024= 1.9
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<pubDate>Thu, 01 Jan 2026 00:00:00 GMT</pubDate>
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<dc:date>2026-01-01T00:00:00Z</dc:date>
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