Browsing Institute's contributions by Author "Varela, M.F."
Now showing items 1-4 of 4
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Bacterial Resistance to Antimicrobial Agents
Varela, M.F.; Stephen, J.; Lekshmi, M.; Ojha, M.; Wenzel, N.; Sanford, L.M.; Hernandez, A.J.; Parvathi, A.; Kumar, S.H. (MDPI AG, 2021)Bacterial pathogens as causative agents of infection constitute an alarming concern in the public health sector. In particular, bacteria with resistance to multiple antimicrobial agents can confound chemotherapeutic efficacy ... -
Efflux Pump-Mediated Quorum Sensing: New Avenues for Modulation of Antimicrobial Resistance and Bacterial Virulence
Lekshmi, M.; Parvathi, A.; Kumar, Sanath; Varela, M.F. (Springer, Singapore, 2018)Bacterial pathogenesis is frequently enhanced by virulence mechanisms that facilitate growth. Such virulence factors include biofilm formation and antimicrobial resistance mechanisms. One primary resistance mechanism ... -
Functional and Structural Roles of the Major Facilitator Superfamily Bacterial Multidrug Efflux Pumps
Sanath, Kumar; Lekshmi, M.; Parvathi, A.; Ojha, M.; Wenzel, N.; Varela, M.F. (MDPI AG, 2020)Pathogenic microorganisms that are multidrug-resistant can pose severe clinical and public health concerns. In particular, bacterial multidrug efflux transporters of the major facilitator superfamily constitute a notable ... -
Identification of a novel UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) from Vibrio fischeri that confers high fosfomycin resistance in Escherichia coli
Kumar, S.; Parvathi, A.; Hernandez, R.L.; Cadle, K.M.; Varela, M.F. (Springer, 2009)MurA [UDP-N-acetylglucosamine (UDP-NAG) enolpyruvyl transferase] is a key enzyme involved in bacterial cell wall peptidoglycan synthesis and a target for the antimicrobial agent fosfomycin, a structural analog of the MurA ...