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dc.contributor.authorShailaja, M.S.
dc.contributor.authorRodrigues, A.
dc.date.accessioned2008-07-18T05:08:36Z
dc.date.available2008-07-18T05:08:36Z
dc.date.issued2003
dc.identifier.citationEstuarine, Coastal and Shelf Science, Vol.56; 1107-1110p.
dc.identifier.urihttp://drs.nio.org/drs/handle/2264/1222
dc.description.abstractCoastal areas are prone to varying degrees of anthropogenic chemical contamination. In many coastal environments experiencing reducing conditions in the water column, nitrite is produced as a result of denitrification. With a view to determining the effect of a natural stress such as the presence of nitrite in water on the xenobiotic metabolism in fish, the euryhaline cichlid Oreochromis mossambicus was exposed for up to 9 days to environmentally relevant concentrations of water-borne nitrite and phenanthrene, a polycyclic aromatic hydrocarbon. Analyses of different biomarkers in the treated fish indicated significant increase in the metabolism of phenanthrene as a result of exposure to nitrite. For example, the activity of the biotransformation enzyme measured, as 7-ethoxyresorufin-O-deethlase activity was, in the presence of 1 mu M nitrite, nearly twice that produced by phenanthrene alone. Similarly, biliary fixed fluorescence values reflecting phenanthrene and its metabolites were rendered 1.7 times higher when exposed simultaneously to nitrite. Contact with nitrite and phenanthrene together also led to severe hepatic damage with possible cell death as inferred from the large enhancement in sorbitol dehydrogenase activity in the serum and reduced liver somatic index
dc.language.isoen
dc.publisherElsevier
dc.rightsCopyright [2003]. It is tried to respect the rights of the copyright holders to the best of the knowledge. If it is brought to our notice that the rights are violated then the item would be withdrawn.
dc.subjectmarine fish
dc.subjecttoxicity
dc.subjectmarine pollution
dc.subjectpollution effects
dc.subjectaromatic hydrocarbons
dc.subjectliver
dc.subjectdamage
dc.subjectdenitrification
dc.subjectanthropogenic factors
dc.subjectOreochromis massambicus
dc.titleNitrite-induced enhancement of toxicity of phenanthrene in fish and its implications for coastal waters
dc.typeJournal Article


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