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dc.contributor.authorKhan, M.S.
dc.contributor.authorSiddiqui, S.A.
dc.contributor.authorSiddiqui, M.S.R.A.
dc.contributor.authorGoswami, U.
dc.contributor.authorSrinivasan, K.V.
dc.contributor.authorKhan, M.I.
dc.date.accessioned2008-10-17T15:40:32Z
dc.date.available2008-10-17T15:40:32Z
dc.date.issued2008
dc.identifier.citationChemical biology & drug design, Vol.72; 197-204p.
dc.identifier.urihttp://drs.nio.org/drs/handle/2264/1471
dc.description.abstractSome novel chemically synthesized 2,4,5-trisubstituted imidazoles from aryl aldehydes and 1,2-diketones or a-hydroxyketone were screened against eight different human pathogenic bacteria and fungi. Seven compounds were found to be active against different bacteria. These compounds showed variation in activity and were found to be active against Gram-positive as well as Gram-negative bacteria. Compound 4-(4,5-diphenyl-1H-imidazol-2-yl)-phenol, 3d was the only compound which showed activity against Klebsiella pneumoniae while rest of the compounds did not show significant activity against this micro-organism. Minimum inhibitory concentrations of the compounds were in the range of 0.50 to 6.1 mu g/mL and minimum bactericidal concentration ranges from 1.11 to 12.9 mu g/mL. The candidature of active compounds to be an effective and novel drug was examined based on Lipinski's rule of Five which explained ClogP, LogS, H-bond acceptors, H-Bond donors and rotational bonds. Compounds 3aûd and 3f satisfies Lipinski's rule of Five and could be proposed as potent new antibacterial drugs
dc.language.isoen
dc.publisherBlackwell Munksgaard
dc.rightsCopyright [2008]. All efforts have been made to respect the copyright to the best of our knowledge. Inadvertent omissions, if brought to our notice, stand for correction and withdrawal of document from this repository.
dc.subjectAntibacterial activity
dc.subjectpathogenic bacteria
dc.titleAntibacterial activity of synthesized 2,4,5-trisubstituted imidazole derivatives
dc.typeJournal Article


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