A heteroaromatic acid from marine sponge Suberites vestigium

Abstract

The 4-Methyl- pyrazole-3(5)-carboxylic acid has been isolated from the buttanol fraction of marine sponge, Sunerites vestigium for the first time. The methanol extract of the sponge exhibits in vitro antihistaminic activity. Pyrazole derivatives as synthetic products are widely used as medicine, however, organic compounds containing pyrazole nucleus have not been reported from marine flora and fauna. Structure elucidation of the compound is based on spectral evidences.