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    Aspernolides A and B, butenolides from a marine-derived fungus Aspergillus terreus

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    Phytochemistry_70_128p.pdf (138.4Kb)
    Date
    2009
    Author
    Parvatkar, R.R.
    DeSouza, C.
    Tripathi, A.
    Naik, C.G.
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    Abstract
    Two aromatic butenolides, aspernolides A and B along with the known metabolites, butyrolactone I, terrein and physcion were isolated from the fermentation broth of a soft coral derived fungus Aspergillus terreus. The structures of these metabolites were assigned on the basis of detailed spectroscopic analysis. The absolute stereochemistry of aspernolides A (1) and B (2) was established by their preparation from the known butyrolactone I. Biogenetically aspernolides A and B must be derived from butyrolactone I, a well known specific inhibitor of cyclin dependent kinase (cdk) from A. terreus. When tested, aspernolide A exhibited mild cytotoxicity against cancer cell lines
    URI
    http://drs.nio.org/drs/handle/2264/2611
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