(-)-6 alpha hydroxy polyanthellian A - A novel antifouling diterpenoid from the Indian soft coral Cladiella krempfi (Hickson)
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Date
2011Author
LimnaMol, V.P.
Raveendran, T.V.
Parameswaran, P.S.
Kunnath, R.J.
Rajamohanan, P.R.
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Bioassay-guided purification of methanol extract of the soft coral Cladiella krempfi (Octocorallia: Alcynocea) yielded a novel eunicellin-type diterpenoid, (-)-6 alpha-hydroxy polyanthellin A (1), active against the cyprids of the fouling barnacle, Balanus amphitrite (EC sub(50) 9.02 mu g/mL; LC sub(50) 36 mg/mL; and therapeutic ratio = 4). The structure of compound 1 was determined from its spectral data, including IR, NMR (1D and 2D NMR), and mass spectra
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