Show simple item record

Chemistry of the nudibranch Aldisa andersoni: Structure and biological activity of phorbazole metabolites

dc.contributor.authorNuzzo, G.
dc.contributor.authorCiavatta, M.L.
dc.contributor.authorKiss, R.
dc.contributor.authorMathieu, V.
dc.contributor.authorLeclercqz, H.
dc.contributor.authorManzo, E.
dc.contributor.authorVillani, G.
dc.contributor.authorMollo, E.
dc.contributor.authorLefranc, F.
dc.contributor.authorDeSouza, L.
dc.contributor.authorGavagnin, M.
dc.contributor.authorGuido Cimino, G.
dc.date.accessioned2012-09-03T09:05:39Z
dc.date.available2012-09-03T09:05:39Z
dc.date.issued2012
dc.identifier.citationMarine Drugs, vol.10; 2012; 1799-1811
dc.identifier.urihttp://drs.nio.org/drs/handle/2264/4143
dc.description.abstractA chemical study of the Indo-Pacific dorid nudibranch Aldisa andersoni resulted in the isolation of five chlorinated phenyl-pyrrolyloxazoles belonging to the phorbazole series. Two new molecules, 9-chloro-phorbazole D and N1-methyl-phorbazole A, co-occurring with known phorbazoles A, B and D, have been characterized. Phorbazoles were found to be present mainly in the external part of the mollusc. The structures of the new compounds were determined by interpretation of spectroscopic data, mainly NMR and mass spectrometry and by comparison with the literature data. Evaluation of feeding-deterrence activity as well as in vitro growth inhibitory properties in human cancer cells was also carried out.
dc.language.isoen
dc.publisherMDPI Publishing
dc.rightsOPEN ACCESS
dc.subjectgrowth regulators
dc.subjectinhibitors
dc.subjectfeeding behaviour
dc.subjectAldisa andersoni
dc.titleChemistry of the nudibranch Aldisa andersoni: Structure and biological activity of phorbazole metabolites
dc.typeJournal Article


Files in this item

Thumbnail
Name:
Mar_Drugs_10_1799.pdf
Size:
515.2Kb
Format:
PDF
View/Open

This item appears in the following Collection(s)

Show simple item record