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dc.contributor.authorMajik, M.S.
dc.contributor.authorNaik, D.
dc.contributor.authorBhat, C.
dc.contributor.authorTilve, S.
dc.contributor.authorTilvi, S.
dc.contributor.authorDeSouza, L.
dc.date.accessioned2013-04-02T10:03:15Z
dc.date.available2013-04-02T10:03:15Z
dc.date.issued2013
dc.identifier.citationBioorganic & Medicinal Chemistry Letters, vol.23; 2013; 2353-2356
dc.identifier.otherno
dc.identifier.urihttp://drs.nio.org/drs/handle/2264/4277
dc.description.abstract(R)-Bgugaine is a natural pyrrolidine alkaloid from Arisarum vulgare, which shows antifungal and antibacterial activity. We have accomplished the simple synthesis of norbgugaine (demethylated form of natural bgugaine) employing Wittig olefination and cat hydrogenation as the key steps and its biological studies are reported for the first time. The synthesized norbgugaine was evaluated for inhibition of quorum sensing mediated virulence factors (motility, biofilm formation, pyocyanin pigmentation, rhamnolipid production and LasA protease) in Pseudomonas aeruginosa wherein swarming motility is reduced by 95 percent, and biofilm formation by 83 percent.
dc.language.isoen
dc.publisherElsevier
dc.relation.requiresBioorg_Med_Chem_Lett_23_2353.jpg
dc.rightsAn edited version of this paper was published by Elsevier. Copyright [2013] Elsevier
dc.subjectinhibitors
dc.subjectantibiotics
dc.subjectfungicides
dc.subjectantifouling substances
dc.titleSynthesis of (R)-norbgugaine and its potential as quorum sensing inhibitor against Pseudomonas aeruginosa
dc.typeJournal Article


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