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dc.contributor.authorMahajan, G.B.
dc.contributor.authorThomas, B.
dc.contributor.authorParab, R.
dc.contributor.authorPatel, Z.E.
dc.contributor.authorKuldharan, S.
dc.contributor.authorYemparala, V.
dc.contributor.authorMishra, P.D.
dc.contributor.authorRanadive, P.
dc.contributor.authorDeSouza, L.
dc.contributor.authorPari, K.
dc.contributor.authorSivaramkrishnan, H.
dc.date.accessioned2013-12-10T05:55:35Z
dc.date.available2013-12-10T05:55:35Z
dc.date.issued2013
dc.identifier.citationAntimicrobial Agents and Chemotherapy, vol.57(11); 2013; 5315-5319
dc.identifier.urihttp://drs.nio.org/drs/handle/2264/4401
dc.description.abstractDrug resistance has become a global threat that, if not addressed, may return us to the preantibiotic era. A way to overcome the problem of growing incidence of global antibiotic resistance is to introduce compounds belonging to classes that are new to the clinic. During a screening of the marine microbial extract library for new antibiotics, one of the extracts showed promising antibacterial activity against Gram-positive organisms. Bioactivity-guided isolation and characterization of active metabolites led to the discovery of a novel thiazolyl cyclic-peptide antibiotic, PM181104. It was isolated and characterized from a marine sponge-associated actinobacterium strain of the genus Kocuria (MTCC 5269). The compound exhibited a potent in vitro antibacterial activity against a broad range of Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE). The MIC values evaluated for the compound were found to be in the single-digit nanomolar range. In in vivo studies of PM181104 in a BALB/c murine septicemia model, the compound displayed 100% effective dose (ED100) values of 2.5 and 5.0 mg/kg of body weight against MRSA and 10.0 mg/kg against VRE. In this report, in vitro and in vivo studies of PM181104 are described
dc.language.isoen
dc.publisherAmerican Society for Microbiology
dc.rightsopyright © American Society for Microbiology
dc.subjectantibiotics
dc.subjectbacteria
dc.subjectbioactive compounds
dc.subjectsponges
dc.titleIn vitro and in vivo activities of antibiotic PM181104
dc.typeJournal Article


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