dc.contributor.author | Mahajan, G.B. | |
dc.contributor.author | Thomas, B. | |
dc.contributor.author | Parab, R. | |
dc.contributor.author | Patel, Z.E. | |
dc.contributor.author | Kuldharan, S. | |
dc.contributor.author | Yemparala, V. | |
dc.contributor.author | Mishra, P.D. | |
dc.contributor.author | Ranadive, P. | |
dc.contributor.author | DeSouza, L. | |
dc.contributor.author | Pari, K. | |
dc.contributor.author | Sivaramkrishnan, H. | |
dc.date.accessioned | 2013-12-10T05:55:35Z | |
dc.date.available | 2013-12-10T05:55:35Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | Antimicrobial Agents and Chemotherapy, vol.57(11); 2013; 5315-5319 | |
dc.identifier.uri | http://drs.nio.org/drs/handle/2264/4401 | |
dc.description.abstract | Drug resistance has become a global threat that, if not addressed, may return us to the preantibiotic era. A way to overcome the problem of growing incidence of global antibiotic resistance is to introduce compounds belonging to classes that are new to the clinic. During a screening of the marine microbial extract library for new antibiotics, one of the extracts showed promising antibacterial activity against Gram-positive organisms. Bioactivity-guided isolation and characterization of active metabolites led to the discovery of a novel thiazolyl cyclic-peptide antibiotic, PM181104. It was isolated and characterized from a marine sponge-associated actinobacterium strain of the genus Kocuria (MTCC 5269). The compound exhibited a potent in vitro antibacterial activity against a broad range of Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE). The MIC values evaluated for the compound were found to be in the single-digit nanomolar range. In in vivo studies of PM181104 in a BALB/c murine septicemia model, the compound displayed 100% effective dose (ED100) values of 2.5 and 5.0 mg/kg of body weight against MRSA and 10.0 mg/kg against VRE. In this report, in vitro and in vivo studies of PM181104 are described | |
dc.language.iso | en | |
dc.publisher | American Society for Microbiology | |
dc.rights | opyright © American Society for Microbiology | |
dc.subject | antibiotics | |
dc.subject | bacteria | |
dc.subject | bioactive compounds | |
dc.subject | sponges | |
dc.title | In vitro and in vivo activities of antibiotic PM181104 | |
dc.type | Journal Article | |