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dc.contributor.authorParvatkar, P.T.
dc.contributor.authorAjay, A.K.
dc.contributor.authorBhat, M.K.
dc.contributor.authorParameswaran, P.S.
dc.contributor.authorTilve, S.G.
dc.date.accessioned2014-01-13T08:46:56Z
dc.date.available2014-01-13T08:46:56Z
dc.date.issued2013
dc.identifier.citationMedicinal Chemistry Research, vol.22(1); 2013; 88–93
dc.identifier.urihttp://drs.nio.org/drs/handle/2264/4423
dc.description.abstractThis article describes a facile one-pot synthesis of different chloro-substituted linear and angular indoloquinolines using iodine as a catalyst and in vitro antiproliferative activity of these chloro-substituted indoloquinolines (3e and 3f) and some indolo[2,3-b]quinolines (3a–d) against human hepatocellular carcinoma HepG2 and human breast carcinoma MCF-7 cells. Anti-proliferative assay against human hepatocellular carcinoma HepG2 and human breast carcinoma MCF-7 cells indicated methyl-substituted 6H-indolo[2,3-b]quinoline 3c to be the most active and the parent 6H-indolo[2,3-b]quinoline 3a to be the least active, while the other compounds including the different chloro derivatives exhibited only intermediate activity.
dc.language.isoen
dc.publisherSpringer
dc.rightsAn edited version of this paper was published by Springer. This paper is for R & D purpose and Copyright [2013] Springer.
dc.subjectAlkaloid
dc.subjectAntiproliferative activity
dc.subjectIndoloquinoline
dc.titleIodine catalyzed one-pot synthesis of chloro-substituted linear and angular indoloquinolines and in vitro antiproliferative activity study of different indoloquinolines
dc.typeJournal Article


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