dc.contributor.author | Parvatkar, P.T. | |
dc.contributor.author | Ajay, A.K. | |
dc.contributor.author | Bhat, M.K. | |
dc.contributor.author | Parameswaran, P.S. | |
dc.contributor.author | Tilve, S.G. | |
dc.date.accessioned | 2014-01-13T08:46:56Z | |
dc.date.available | 2014-01-13T08:46:56Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | Medicinal Chemistry Research, vol.22(1); 2013; 88–93 | |
dc.identifier.uri | http://drs.nio.org/drs/handle/2264/4423 | |
dc.description.abstract | This article describes a facile one-pot synthesis of different chloro-substituted linear and angular indoloquinolines using iodine as a catalyst and in vitro antiproliferative activity of these chloro-substituted indoloquinolines (3e and 3f) and some indolo[2,3-b]quinolines (3a–d) against human hepatocellular carcinoma HepG2 and human breast carcinoma MCF-7 cells. Anti-proliferative assay against human hepatocellular carcinoma HepG2 and human breast carcinoma MCF-7 cells indicated methyl-substituted 6H-indolo[2,3-b]quinoline 3c to be the most active and the parent 6H-indolo[2,3-b]quinoline 3a to be the least active, while the other compounds including the different chloro derivatives exhibited only intermediate activity. | |
dc.language.iso | en | |
dc.publisher | Springer | |
dc.rights | An edited version of this paper was published by Springer. This paper is for R & D purpose and Copyright [2013] Springer. | |
dc.subject | Alkaloid | |
dc.subject | Antiproliferative activity | |
dc.subject | Indoloquinoline | |
dc.title | Iodine catalyzed one-pot synthesis of chloro-substituted linear and angular indoloquinolines and in vitro antiproliferative activity study of different indoloquinolines | |
dc.type | Journal Article | |