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dc.contributor.authorMajik, M.S.
dc.contributor.authorRodrigues, C.
dc.contributor.authorMascarenhas, S.
dc.contributor.authorDeSouza, L.
dc.date.accessioned2014-07-22T10:33:49Z
dc.date.available2014-07-22T10:33:49Z
dc.date.issued2014
dc.identifier.citationBioorganic Chemistry, vol.54; 2014; 89-95.
dc.identifier.otherno
dc.identifier.urihttp://drs.nio.org/drs/handle/2264/4552
dc.description.abstractMarine organisms such as seaweeds, sponges and corals protect their own surfaces from fouling by their high anesthetic, repellant, and settlement inhibition properties. Within the marine ecosystem, evolution has allowed for the development of certain antifouling properties. Isatin is a biologically active chemical produced by an Alteromonas sp. strain inhibiting the surface of embryos of the cardiean shrimp Palaemon macrodectylus, which protect them from the pathogenic fungus Lagenidium callinectes. In present study, an antibacterial activity of isatin and its synthetic analogues were evaluated against different fouling bacteria in order to explore the structure activity relationships for the first time. The synthesized compounds along with parent isatin were tested against different ecologically relevant marine microorganisms by using the Kirby–Bauer disc diffusion method. Few synthetically modified isatin exhibited potent inhibitory activity at concentration of 2 μg/disc against Planococcus donghaensis, Erythrobacter litoralis, Alivibrio salmonicida, Vibrio furnisii. Overall, the modified analogues showed stronger activity than the parent marine natural product (isatin) and hence 1H-indole-2,3-dione scaffold has immense potential as future antibacterial/antifouling candidate.
dc.language.isoen
dc.publisherElsevier
dc.relation.requiresBioorg_Chem_54_89.jpg
dc.rightsAn edited version of this paper was published by Elsevier. Copyright [2014] Elsevier
dc.subjectMarine natural product
dc.subjectMarine organisms
dc.subjectMarine ecosystem
dc.titleDesign and synthesis of marine natural product-based 1H-indole-2,3-dione scaffold as a new antifouling/antibacterial agent against fouling bacteria.
dc.typeJournal Article


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