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dc.contributor.authorPrabhaDevi
dc.contributor.authorRavichandran, S.
dc.contributor.authorRibeiro, M.
dc.contributor.authorCiavatta, M.L.
dc.date.accessioned2014-09-19T09:57:42Z
dc.date.available2014-09-19T09:57:42Z
dc.date.issued2013
dc.identifier.citationOceanography: Open Access, vol.1(3); 2013; 4p. doi:10.4172/2332-2632.1000112
dc.identifier.urihttp://drs.nio.org/drs/handle/2264/4608
dc.description.abstracthe need for discovery of new antibiotics is imperative because previous evidence suggest that development of resistance to any new antimicrobial agents is inevitable. In addition, compounds not tested for antimicrobial activity also gives ample scope for rediscovering compounds with antimicrobial activity. This study screens extracts (Diethyl Ether and Butanol) of a marine red-Sea sponge Negombata magnifica for invitro fungicidal activity against 10 plant and 3 fish pathogens. Fungicidal activity of the crude diethylether fraction of the sponge against test strains showed exceptionally high activity against three virulent fish pathogens Exophiala salmonis, Branchiomyces demigrans and Saprolegnia sp. Furthermore, Minimal Inhibitory Concentration (MIC) of the compound was evaluated with respect to Exophiala salmonis (1.5 µg/ml) Branchiomyces demigrans (0.75 µg/ml) and Saprolegnia sp (3 µg/ml) respectively. Finally, bioassay guided isolation and purification led to the identification of the active compound as latrunculin B on the basis of spectroscopic data. This finding suggests that latrunculin B, could be considered as a lead molecule for the design of new antifungals for managing common fungal diseases in aquaculture. Toxicity testing of this compound on shrimps indicated that the compound was non toxic up to a concentration as high as 5 mg/ml suggesting its suitability for use in aquaculture.
dc.language.isoen
dc.publisherOMICS Group
dc.rightsCopyright: © 2013 Devi P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
dc.subjectsponges
dc.subjectfungicides
dc.subjectbioactive compounds
dc.subjectfish diseases
dc.titleAntifungal potential of marine sponge extract against plant and fish pathogenic fungi
dc.typeJournal Article


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