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dc.contributor.authorNita-Lazar, M.
dc.contributor.authorMancini, J.
dc.contributor.authorFeng, C.
dc.contributor.authorGonzalez-Montalban, N.
dc.contributor.authorRavindran, C.
dc.contributor.authorJackson, S.
dc.contributor.authorHeras-Sanchez, A.D.L.
dc.contributor.authorGiomarelli, B.
dc.contributor.authorAhmed, H.
dc.contributor.authorHaslam, S.M.
dc.contributor.authorWu, G.
dc.contributor.authorDell, A.
dc.contributor.authorAmmayappan, A.
dc.contributor.authorVakharia, V.N.
dc.contributor.authorVasta, G.R.
dc.date.accessioned2016-02-04T04:46:05Z
dc.date.available2016-02-04T04:46:05Z
dc.date.issued2016
dc.identifier.citationDevelopmental and Comparative Immunology, vol.55; 2016; 241-252
dc.identifier.urihttp://drs.nio.org/drs/handle/2264/4900
dc.description.abstractThe infectious hematopoietic necrosis virus (IHNV; Rhabdoviridae, Novirhabdovirus) infects teleost fish, such as salmon and trout, and is responsible for significant losses in the aquaculture industry and in wild fish populations. Although IHNV enters the host through the skin at the base of the fins, the viral adhesion and entry mechanisms are not fully understood. In recent years, evidence has accumulated in support of the key roles played by protein-carbohydrate interactions between host lectins secreted to the extracellular space and virion envelope glycoproteins in modulating viral adhesion and infectivity. In this study, we assessed in vitro the potential role(s) of zebrafish (Danio rerio) proto type galectin-1 (Drgal1-L2) and a chimera galectin-3 (Drgal3-L1) in IHNV adhesion to epithelial cells. Our results suggest that the extracellular Drgal1-L2 and Drgal3-L1 interact directly and in a carbohydrate-dependent manner with the IHNV glycosylated envelope and glycans on the epithelial cell surface, significantly reducing viral adhesion
dc.language.isoen
dc.publisherElsevier
dc.rightsAn edited version of this paper was published by Elsevier. Copyright [2015] Elsevier
dc.subjectAQUACULTURE::Diseases of Cultured Organisms
dc.subjectICHTHYOLOGY::General
dc.subjectICHTHYOLOGY::Physiology, biochemistry, biophysics
dc.titleThe zebrafish galectins Drgal1-L2 and Drgal3-L1 bind in vitro to the infectious hematopoietic necrosis virus (IHNV) glycoprotein and reduce viral adhesion to fish epithelial cells
dc.typeJournal Article


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