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    Kahalalide F analogues from the mucous secretion of Indian sacoglossan mollusc Elysia ornata

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    Tetrahedron_72_625a.pdf (229.0Kb)
    Date
    2016
    Author
    Ciavatta, M.L.
    PrabhaDevi
    Carbone, M.
    Mathieu, V.
    Kiss, R.
    Casapullo, A.
    Gavagnin, M.
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    Abstract
    Bioassay-guided fractionation of the CHCl<sub>3</sub>/MeOH extract of Elysia ornata mucus showing antifungal activity led us to isolate kahalalide F(KF) along with two unprecedented related peptides. The structures of kahalalide Z<sub>2</sub>(1) and kahalalide Z<sub>2</sub>(2), were established by combination of NMR spectroscopic and mass spectrometry data, also including Marfey amino acid analysis. Compounds 1 and 2 displayed significant antimicrobial properties against several fungal pathogens infesting economically important plants, food, and fish, and were also found to inhibit the in vitro growth of a series of cancer cell lines in a comparable fashion with KF
    URI
    http://drs.nio.org/drs/handle/2264/4902
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