Kahalalide F analogues from the mucous secretion of Indian sacoglossan mollusc Elysia ornata
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Date
2016Author
Ciavatta, M.L.
PrabhaDevi
Carbone, M.
Mathieu, V.
Kiss, R.
Casapullo, A.
Gavagnin, M.
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Bioassay-guided fractionation of the CHCl<sub>3</sub>/MeOH extract of Elysia ornata mucus showing antifungal activity led us to isolate kahalalide F(KF) along with two unprecedented related peptides. The structures of kahalalide Z<sub>2</sub>(1) and kahalalide Z<sub>2</sub>(2), were established by combination of NMR spectroscopic and mass spectrometry data, also including Marfey amino acid analysis. Compounds 1 and 2 displayed significant antimicrobial properties against several fungal pathogens infesting economically important plants, food, and fish, and were also found to inhibit the in vitro growth of a series of cancer cell lines in a comparable fashion with KF
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