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    New bioactive hydrogenated linderazulene-derivatives from the gorgonian Echinogorgia complexa

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    Tetrahedron_Lett_48_2569.pdf (83.24Kb)
    Date
    2007
    Author
    Manzo, E.
    Ciavatta, M.L.
    Gresa, M.P.L.
    Gavagnin, M.
    Villani, G.
    Naik, C.G.
    Cimino, G.
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    Abstract
    Chemical analysis of the secondary metabolite pattern of the gorgonian Echinogorgia complexa, collected along South Indian coasts, showed the presence of two new tricyclic guaiane furanosesquiterpenes, iso-echinofuran (3) and 8,9-dihydro-linderazulene (4), co-occurring with the known echinofuran (5) and structurally related to the pigment linderazulene (1). The unprecedented molecules 3 and 4 were characterized by spectral methods, mainly by NMR techniques. Compounds 3-5 displayed moderate activity in the mitochondrial respiratory chain inhibition assay.
    URI
    http://drs.nio.org/drs/handle/2264/595
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