Disease symptoms and growth performance of grey mullet infected with Myroides odoratimimus
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Date
2017Author
Ravindran, C.
Vasudevan, L.
VinothKannan, S.R.B.
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M. odoratimimus behave as low-grade opportunistic pathogen was isolated from the gut of Mugil cephalus, which infers M. cephalus, a vector for the pathogen entry to human patients. The isolated M. odoratimimus showed potential infectivity to the experimental grey mullet and acted as an ultimate pathogen with significant symptoms such as anorexia, skin hemorrhage, reddening, abdominal distention and external black patches. The median lethal dose (LD50) of the bacteria was 3 x 106 CFU fish-1. In order to assay the accuracy of infection, the production of reactive oxygen species (ROS), the respiratory burst activity of blood leukocytes of mullet before and after challenge was measured, an indicator of the innate immune system. The mullet infection increased the respiratory burst activity and superoxide dismutase activity. In addition, the innate immune response of TLR 9 expression against M. odoratimimus infection and CpG ODN treatment in disease model, zebrafish confirms the M. odoratimimus infection and pathogenicity
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