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dc.contributor.authorSingh, N.
dc.contributor.authorBhagat, J.
dc.contributor.authorIngole, B.S.
dc.date.accessioned2018-06-06
dc.date.accessioned2018-10-23T09:24:58Z
dc.date.available2017-06-16
dc.date.available2018-10-23T09:24:58Z
dc.date.issued2017
dc.identifier.citationEnvironmental Monitoring and Assessment, vol.189(7); 2017; 308
dc.identifier.issn0167-6369
dc.identifier.urihttps://doi.org/10.1007/s10661-017-5993-4
dc.identifier.urihttp://drs.nio.org/drs/handle/2264/7842
dc.description.abstractThe present study explores the in vivo and in vitro genotoxic effects of lead nitrate, [Pb(NO3)2] a recognized environmental pollutant and cobalt chloride (CoCl2), an emerging environmental pollutant in polychaete Perinereis cultrifera using comet assay. Despite widespread occurrence and extensive industrial applications, no previous published reports on genotoxicity of these compounds are available in polychaete as detected by comet assay. Polychaetes were exposed in vivo to Pb(NO3)2 (0, 100, 500, and 1000 ?g/l) and CoCl2 (0, 100, 300, and 500 ?g/l) for 5 days. At 100 ?g/l Pb(NO3)2 concentration, tail DNA (TDNA) values in coelomocytes were increase by 1.16, 1.43, and 1.55-fold after day 1, day 3, and day 5, whereas, OTM showed 1.12, 2.33, and 2.10-fold increase in in vivo. Pb(NO3)2 showed a concentration and time-dependent genotoxicity whereas CoCl2 showed a concentration-dependent genotoxicity in in vivo. A concentration-dependent increase in DNA damage was observed in in vitro studies for Pb(NO3)2 and CoCl2. DNA damage at 500 ?g/L showed almost threefold increase in TDNA and approximately fourfold increase in OTM as compared to control in in vitro. Our studies suggest that Pb(NO3)2 and CoCl2 have potential to cause genotoxic damage, with Pb(NO3)2 being more genotoxic in polychaete and should be used more carefully in industrial and other activities.
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofEnviron Monit Assess
dc.relation.isreferencedbySCI
dc.titleGenotoxicity of two heavy metal compounds: lead nitrate and cobalt chloride in Polychaete Perinereis cultrifera
dc.typeJournal Article
dc.affiliation.authorCSIR-National Institute of Oceanography, Dona Paula, Goa, India


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