dc.contributor.author | Banerjee, S. | |
dc.contributor.author | Phadte, A.A. | |
dc.contributor.author | Chattopadhyay, A. | |
dc.contributor.author | Fernandes, J.R.D. | |
dc.contributor.author | Savardekar, A.V. | |
dc.contributor.author | Banerjee, A. | |
dc.contributor.author | Singh, K.S. | |
dc.date.accessioned | 2019/03/31 | |
dc.date.accessioned | 2019-04-30T12:44:14Z | |
dc.date.available | 2018/10/17 | |
dc.date.available | 2019-04-30T12:44:14Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Tetrahedron Letters, vol.59(42); 2018; 3787-3791 | |
dc.identifier.issn | 0040-4039 | |
dc.identifier.uri | https://doi.org/10.1016/J.TETLET.2018.09.013 | |
dc.identifier.uri | http://drs.nio.org/drs/handle/2264/7968 | |
dc.description.abstract | Aza- and oxa-dihydrotetracenes were prepared in one step from 1,4-dicyanodibenzodioxins in good yields. These molecules represent the first examples of heterocyclic dihydrotetracenes with push-pull character. Aza-dihydrotetracene 18H showed a strong red-shifted absorbance maxima at 472-nm, nearly equal in intensity to the parent band at 260-nm, in polar DMSO medium. The fluorescence emission spectrum of aza-dihydrotetracene 18H had an emission maximum at 525-nm with a broad band stretched out as far as 650-nm. The fluorescence emission quantum yield was almost as strong as the known fluorescent standard 1,3-diphenylisobenzofuran. The aza-dihydrotetracenes exhibited in vitro cytotoxicity against the HeLa cell line and were non-toxic against the normal HaCaT cell line. The fluorescence emerging from HeLa cells incubated with aza-dihydrotetracene 18H was very strong and helped detect the cells microscopically using appropriate filters. A useful future application of the compound could be as a fluorescence based dye in cellular microscopy. | |
dc.language | en | |
dc.publisher | Elsevier | |
dc.relation.isreferencedby | SCI | |
dc.title | Synthesis and photophysical characterization of heterocyclic dihydrotetracenes and their utility in the fluorescence imaging of HeLa cells | |
dc.type | Journal Article | |
dc.affiliation.author | Birla Institute of Technology and Science-Pilani, K.K. Birla Goa Campus, NH-17B Bypass, Zuarinagar, Goa 403726, India | |