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    Isolation and structure elucidation of halymeniaol, a new antimalarial sterol derivative from the red alga Halymenia floresii

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    Date
    2018
    Author
    Meesala, S.
    Gurung, P.
    Karmodiya, K.
    Parameswaran, P.S.
    Watve, M.G.
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    Abstract
    A new mono-hydroxy acetylated sterol derivative: 12?-hydroxy-3?, 15?, 16?-triacetoxy-cholest-5-en-7-one (halymeniaol) (1), and cholesterol (2) were isolated from the marine red alga Halymenia floresii. The structure of the compound 1 (halymeniaol) was established from its spectral data, derived from HRMS/MS and 2D NMR. Compound 1 exhibited growth inhibitory activity against chloroquine-resistant Plasmodium falciparum 3D7 strain with an IC50 of 3.0 ?M.
    URI
    https://doi.org/10.1080/10286020.2017.1342636
    http://drs.nio.org/drs/handle/2264/8176
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