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dc.contributor.authorSanath, Kumar
dc.contributor.authorLekshmi, M.
dc.contributor.authorParvathi, A.
dc.contributor.authorOjha, M.
dc.contributor.authorWenzel, N.
dc.contributor.authorVarela, M.F.
dc.date.accessioned2020-03-31
dc.date.accessioned2021-02-09T10:13:23Z
dc.date.available2020-02-16
dc.date.available2021-02-09T10:13:23Z
dc.date.issued2020
dc.identifier.citationMicroorganisms, vol.8(2); 2020; Article no: 266
dc.identifier.issn2076-2607
dc.identifier.otherhttps://www.mdpi.com/2076-2607/8/2/266
dc.identifier.urihttps://doi.org/10.3390/microorganisms8020266
dc.identifier.urihttp://drs.nio.org/drs/handle/2264/8561
dc.descriptionIF2018 - 4.167
dc.description.abstractPathogenic microorganisms that are multidrug-resistant can pose severe clinical and public health concerns. In particular, bacterial multidrug efflux transporters of the major facilitator superfamily constitute a notable group of drug resistance mechanisms primarily because multidrug-resistant pathogens can become refractory to antimicrobial agents, thus resulting in potentially untreatable bacterial infections. The major facilitator superfamily is composed of thousands of solute transporters that are related in terms of their phylogenetic relationships, primary amino acid sequences, two- and three-dimensional structures, modes of energization (passive and secondary active), and in their mechanisms of solute and ion translocation across the membrane. The major facilitator superfamily is also composed of numerous families and sub-families of homologous transporters that are conserved across all living taxa, from bacteria to humans. Members of this superfamily share several classes of highly conserved amino acid sequence motifs that play essential mechanistic roles during transport. The structural and functional importance of multidrug efflux pumps that belong to the major facilitator family and that are harbored by Gram-negative and -positive bacterial pathogens are considered here.
dc.languageen
dc.publisherMDPI AG
dc.relation.ispartofMicroorganisms
dc.relation.isreferencedbySCI
dc.rightsOnly the author version of the copright reserved papers uploaded. Contact drs@nio.org for any complaints regarding copyright violations
dc.titleFunctional and Structural Roles of the Major Facilitator Superfamily Bacterial Multidrug Efflux Pumps
dc.typeJournal Article
dc.affiliation.authorICAR-Central Institute of Fisheries Education, Seven Bungalows, Andheri (W), Mumbai 400016, India


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