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dc.contributor.authorRethnaPriya, E.
dc.contributor.authorRavichandran, S.
dc.contributor.authorGobinath, T.
dc.contributor.authorTilvi, S.
dc.contributor.authorPrabhaDevi
dc.date.accessioned2020-03-31
dc.date.accessioned2021-02-09T10:13:24Z
dc.date.available2019-07-01
dc.date.available2021-02-09T10:13:24Z
dc.date.issued2019
dc.identifier.citationChemistry and Physics of Lipids, vol.221; 2019; 73-82
dc.identifier.issn1873-2941
dc.identifier.otherhttps://www.sciencedirect.com/science/article/abs/pii/S000930841830241X
dc.identifier.urihttps://doi.org/10.1016/j.chemphyslip.2019.03.010
dc.identifier.urihttp://drs.nio.org/drs/handle/2264/8572
dc.descriptionIF2018 - 2.536
dc.description.abstractSphingolipids have been considered for many years only as structural components of membranes. It is now acknowledged that they are also involved in controlling cellular processes such as proliferation.The present work was designed to find the anticancer activity of the crab Dromia dehanni hemolymph in in-vivo and in vitro with special reference to the anticancer compound sphingolipids isolation and characterization. The active fraction of the purified hemolymph was subjected to NMR and ESI-MS/MS analysis. The ESI-MS/MS spectrum exhibited intense signals for sodiated molecular ions [M + Na] + of sphingomyelins (SM) identified as N-2-O-Acetyl-12 pentadecenoyl sphingosine phosphorylcholine, N-9-eicosenoyl- sphinganine phosphocholine and the corresponding dehydro sphingomyelin, N-9-eicosenoyl- dehydro- sphinganine phosphocholine along with the ions at m/z 147, 184 characteristic of phosphocholine. The present study revealed D. dehaani might be a great source for the novel anti-cancer compounds which can be used for human benefits.
dc.languageen
dc.publisherElsevier Ireland Ltd
dc.relation.ispartofChem Phys Lipids
dc.relation.isreferencedbySCI
dc.rightsOnly the author version of the copright reserved papers uploaded. Contact drs@nio.org for any complaints regarding copyright violations
dc.titleFunctional characterization of anti-cancer sphingolipids from the marine crab Dromia dehanni
dc.typeJournal Article
dc.affiliation.authorCentre of Advanced Study in Marine Biology, Faculty of Marine Sciences, Annamalai University, Parangipettai, 608 502, India


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