Application of 3D cell culture techniques in cosmeceutical research
Abstract
Cosmetic products and their use are an integral part of daily life. People are well aware of the benefits as well as harmful effects associated with the use of synthetic cosmetic products. Therefore, in recent times there has been manifold increased demand for naturally derived cosmetic products, blended with pharmaceutical properties (cosmeceuticals). Traditional approaches for isolation and identification of cosmeceutical compounds using in vitro or two-dimensional (2D) cell-based assays are tedious, time-consuming, and most of the time lack clinical efficacy. As an alternative to 2D cell culture-based approaches for drug discovery, the last decade has witnessed the development of three-dimensional (3D) cell culture-based techniques using various commercially available 3D reconstructed human skin (RHS) models and their different applications in the field of cosmeceutical research. The 3D RHS models exactly mimic the natural human skin, resulting in fascinating drug discoveries from natural resources. This chapter summarizes the application of 3D RHS models for the screening of compounds for their cosmeceutical potential such as skin whitening, antiaging, antiinflammatory, antioxidant, anticancer, skin penetration, skin absorption, skin irritation, phototoxic, and skin wound healing.
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