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dc.contributor.authorTilvi, S.
dc.contributor.authorParvatkar, R.
dc.contributor.authorSingh, K.S.
dc.contributor.authorPrabhaDevi
dc.date.accessioned2021-06-16
dc.date.accessioned2021-06-22T10:08:58Z
dc.date.available2021-02-01
dc.date.available2021-06-22T10:08:58Z
dc.date.issued2021
dc.identifier.citationChemistry and Biodiversity, vol.18(2); 2021; Article no: e2000956
dc.identifier.issn1612-1872
dc.identifier.otherhttps://onlinelibrary.wiley.com/doi/10.1002/cbdv.202000956
dc.identifier.urihttps://doi.org/10.1002/cbdv.202000956
dc.identifier.urihttps://drs-beta.nio.org/drs/handle/2264/8617
dc.descriptionIF2019 - 2.039
dc.description.abstractThe marine fungus, Aspergillus flavipes (MTCC 5220), was isolated from the pneumatophore of a mangrove plant Acanthus ilicifolius found in Goa, India. The crude extract of A. flavipes was found to show anti-inflammatory activity. It blocked interleukin-6 (IL-6) and tumor necrosis factor-? (TNF-?) production in lipopolysaccharide (LPS)-activated THP-1 cells with IC50 of 2.69�0.5??M and 6.64�0.4??M, respectively. The chemical investigation led to the isolation of optically inactive 4?-[(1E)-propen-1-yl]cyclopentane-1?,2?-diol (1) along with a new optically active diastereoisomeric compound, 4?-[(1E)-propen-1-yl]cyclopentane-1?,2?-diol (2). In addition, the fungus also produced known compounds (+)-terrein (3), butyrolactone I (4) and butyrolactone II (5) in high yields. Among these, (+)-terrein (3) exhibited IL-6 and TNF-? inhibition activity with IC50 of 8.5�0.68??M and 15.76�0.18??M, respectively, while butyrolactone I (4) exhibited IC50 of 12.03�0.85??M (IL-6) and 43.29�0.76??M (TNF-?) inhibition activity with low toxicity to host cells in LPS stimulated THP-1 cells. This is the first report of the isolation and characterization of 4?-[(1E)-propen-1-yl]cyclopentane-1?,2?-diol (2). The structures of all the isolated compounds were elucidated on the basis of extensive detailed NMR spectroscopic data. Anti-inflammatory activity of the fungi A. flavipes is presented here for the first time, which was due to (+)-terrein and butyrolactone I, as the major constituents and they can be further explored in the therapeutic area.
dc.languageen
dc.publisherJohn Wiley and Sons, Ltd
dc.relation.isreferencedbySCI
dc.rightsOnly the author version of the copright reserved papers uploaded. Contact drs@nio.org for any complaints regarding copyright violations
dc.titleChemical Investigation of Marine-Derived Fungus Aspergillus flavipes for Potential Anti-Inflammatory Agents
dc.typeJournal Article
dc.affiliation.authorCSIR-National Institute of Oceanography, Dona Paula, Goa, India


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