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dc.contributor.authorDas, Nandita
dc.contributor.authorDas, Ankita
dc.contributor.authorDas, Sandeep
dc.contributor.authorBhatawadekar, V.
dc.contributor.authorPandey, Prisha
dc.contributor.authorChoure, K.
dc.contributor.authorDamare, S.R.
dc.contributor.authorPandey, Piyush
dc.date.accessioned2023-04-12
dc.date.accessioned2023-07-17T15:32:49Z
dc.date.available2023-02-20
dc.date.available2023-07-17T15:32:49Z
dc.date.issued2023
dc.identifier.citationFermentation, vol.9(2); 2023; Article no: 196
dc.identifier.issn2311-5637
dc.identifier.otherhttps://www.mdpi.com/2311-5637/9/2/196
dc.identifier.urihttps://doi.org/10.3390/FERMENTATION9020196
dc.identifier.urihttp://drs.nio.res.in/drs/handle/2264/9039
dc.description5.123
dc.description.abstractAnthropogenic activities and industrial effluents are the major sources of petroleum hydrocarbon contamination in different environments. Microbe-based remediation techniques are known to be effective, inexpensive, and environmentally safe. In this review, the metabolic-target-specific pathway engineering processes used for improving the bioremediation of hydrocarbon-contaminated environments have been described. The microbiomes are characterised using environmental genomics approaches that can provide a means to determine the unique structural, functional, and metabolic pathways used by the microbial community for the degradation of contaminants. The bacterial metabolism of aromatic hydrocarbons has been explained via peripheral pathways by the catabolic actions of enzymes, such as dehydrogenases, hydrolases, oxygenases, and isomerases. We proposed that by using microbiome engineering techniques, specific pathways in an environment can be detected and manipulated as targets. Using the combination of metabolic engineering with synthetic biology, systemic biology, and evolutionary engineering approaches, highly efficient microbial strains may be utilised to facilitate the target-dependent bioprocessing and degradation of petroleum hydrocarbons. Moreover, the use of CRISPR-cas and genetic engineering methods for editing metabolic genes and modifying degradation pathways leads to the selection of recombinants that have improved degradation abilities. The idea of growing metabolically engineered microbial communities, which play a crucial role in breaking down a range of pollutants, has also been explained. However, the limitations of the in-situ implementation of genetically modified organisms pose a challenge that needs to be addressed in future research.
dc.languageen
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.relation.isreferencedbySCI
dc.rightsOnly the author version of the copright reserved papers uploaded. Contact drs@nio.org for any complaints regarding copyright violations
dc.titlePetroleum Hydrocarbon Catabolic Pathways as Targets for Metabolic Engineering Strategies for Enhanced Bioremediation of Crude-Oil-Contaminated Environments
dc.typeJournal Article
dc.affiliation.authorSoil and Environment Microbiology Laboratory, Department of Microbiology, Assam University, Silchar 788011, Assam, India


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