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dc.contributor.authorSurwase,A.J.
dc.contributor.authorThakur, N.L.
dc.date.accessioned2025-01-16
dc.date.accessioned2025-01-21T10:49:48Z
dc.date.available2024-09-16
dc.date.available2025-01-21T10:49:48Z
dc.date.issued2024
dc.identifier.citationBiotechnology Advances,Vol. 77;2024;Article no :108449
dc.identifier.issn0734-9750
dc.identifier.otherhttps://www.sciencedirect.com/science/article/pii/S0734975024001435
dc.identifier.urihttps://doi.org/10.1016/j.biotechadv.2024.108449
dc.identifier.urihttp://drs.nio.res.in/drs/handle/2264/9317
dc.descriptionIF2023= 12.1
dc.description.abstractThis review examines a wide range of marine microbial-derived bioactive peptide molecules, emphasizing the significance of reverse engineering in their production. The discussion encompasses the advancements in Marine Natural Products (MNPs) bio-manufacturing through the integration of omics-driven microbial engineering and bioinformatics. The distinctive features of non-ribosomally synthesised peptides (NRPs), and ribosomally synthesised precursor peptides (RiPP) biosynthesis is elucidated and presented. Additionally, the article delves into the origins of common peptide modifications. It highlights various genome mining approaches for the targeted identification of Biosynthetic Gene Clusters (BGCs) and novel RiPP and NRPs-derived peptides. The review aims to demonstrate the advancements, prospects, and obstacles in engineering both RiPP and NRP biosynthetic pathways.
dc.languageen
dc.publisherElsevier
dc.relation.isreferencedbySCI
dc.rightsOnly the author version of the copright reserved papers uploaded. Contact drs@nio.org for any complaints regarding copyright violations
dc.titleProduction of marine-derived bioactive peptide molecules for industrial applications: A reverse engineering approach
dc.typeJournal Article
dc.affiliation.authorCSIR-National Institute of Oceanography, Dona Paula, Goa, India


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