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dc.contributor.authorParab, A.S.
dc.contributor.authorGhose, M.
dc.contributor.authorManohar, C.S.
dc.date.accessioned2025-08-18
dc.date.accessioned2025-08-18T06:19:14Z
dc.date.available2025-07-09
dc.date.available2025-08-18T06:19:14Z
dc.date.issued2025
dc.identifier.citationEnvironmental Pollution,vol.383;2025; Article no:126793
dc.identifier.issn1873-6424
dc.identifier.otherhttps://www.sciencedirect.com/science/article/pii/S0269749125011662
dc.identifier.urihttps://doi.org/10.1016/j.envpol.2025.126793
dc.identifier.urihttp://drs.nio.res.in/drs/handle/2264/9494
dc.descriptionIF2024= 7.3
dc.description.abstractThe increasing threat of antibiotic resistance is a major global concern affecting human and environmental health. Marine environments, though underexplored, are emerging as significant reservoirs for antibiotic resistance genes (ARGs). This study provides genome-resolved shotgun metagenomic insights into the seasonal and spatial dynamics of ARGs in the chlorophyll maximum zones of the eastern Arabian Sea, focusing on bacterial communities from coastal (30 m) and offshore (600 m) depths. Using a shotgun metagenomic approach, 31 potential ARGs were identified across both non-monsoon and monsoon seasons, with higher abundance observed in offshore stations during the non-monsoon season. Multidrug resistance genes such as blaEFM-1, catB2 and mexK, conferring resistance to carbapenems, chloramphenicol and multiple antibiotics, were prevalent in taxa like Staphylococcus sp., Qipengyuania sp. and Alcanivorax sp. Clinically relevant taxa, including Pseudomonas sp. and Staphylococcus sp., harbored ARGs, which may raise concerns regarding potential seafood-mediated ARG transmission. The significant enrichment and co-localization of mobile genetic elements (MGEs) with ARGs suggest enhanced horizontal gene transfer among native marine bacteria in the offshore environments. However, the limited distribution of ARGs and the absence of associated MGEs during the monsoon season may result from dilution caused by freshwater influx. Comparative functional analysis revealed stress-related functional enrichment in ARG-carrying metagenomic assembled genomes, suggesting environmental stress may enhance the spread of ARGs within offshore microbial communities. These findings challenge the coastal-centric view of marine antibiotic resistance by identifying offshore waters as underrecognized ARG reservoirs. Establishing a genomic baseline for One Health ARG surveillance, this study underscores the urgent need to integrate offshore regions into global monitoring frameworks to protect marine ecosystems and safeguard public health.
dc.languageen
dc.publisherElsevier
dc.relation.isreferencedbySCI
dc.rightsOnly the author version of the copright reserved papers uploaded. Contact drs@nio.org for any complaints regarding copyright violations
dc.titleAntibiotic-resistant bacteria in marine productive zones of the eastern Arabian Sea: Implications for human and environmental health
dc.typeJournal Article
dc.affiliation.authorCSIR-National Institute of Oceanography, Dona Paula, Goa, India


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