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    Increased formation of carcinogenic PAH metabolites in fish promoted by nitrite

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    Environ_Pollut_143_174.pdf (273.7Kb)
    Date
    2006
    Author
    Shailaja, M.S.
    Rajamanickam, R.
    Wahidullah, S.
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    Abstract
    Nitrite (NO2−), a highly reactive chemical species, accumulates in coastal waters as a result of pollution with nitrogenous waste and/or an imbalance in the bacterial processes of nitrification and denitrification. The present study probed the impact of nitrite (NO2−) on the metabolism of polycyclic aromatic hydrocarbons (PAHs) in fish. In a laboratory experiment, exposure of euryhaline fish, Oreochromis mossambicus to industrial effluents containing PAHs in the presence of NO2− enhanced the cytochrome P450-dependent biotransformation activity determined as 7-ethoxyresorufin-O-deethylase (EROD), by nearly 36% compared to the value observed in the absence of NO2− (50.2 ± 6.74 pmol resorufin min−1 g−1 liver). Fixed wavelength fluorescence measurements in bile revealed maximum enhancement to have occurred in the metabolites of benzo[a]pyrene, a carcinogenic PAH. Lasting, sublethal physiological deterioration was apparent in fish exposed simultaneously to an oil refinery effluent and NO2−, from the unremittingly decreasing liver somatic index, even after the withdrawal of the contaminants.
    URI
    http://drs.nio.org/drs/handle/2264/112
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