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    A serine protease inhibitor from hemolymph of green mussel, Perna viridis

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    Bioorg_Med_Chem_Lett_18_3963.pdf (178.9Kb)
    Date
    2008
    Author
    Khan, M.S.
    Goswami, U.
    Rojatkar, S.R.
    Khan, M.I.
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    Abstract
    Bioactivity guided fractions of cell-free hemolymph of bacterially challenged marine mussel, Perna viridis led to the isolation of a novel quaternary alkaloid 1, which was identified by its spectral data. The isolated molecule 1 has been found to be a potent serine protease inhibitor (SPI) showing IC sub(50) and K sub(i) values of 102.5 and 97.1-104.68 mu M, respectively. The E sub(t)/K sub(i) value of SPI is 6.3, whereas E sub(t)/K sub(m) value is 1.04. The Van't Hoff analysis showed that the value of K sub(i) decreases with increase in temperature, and the binding of the inhibitor is entropically driven.
    URI
    http://drs.nio.org/drs/handle/2264/1302
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