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dc.contributor.authorKhan, M.S.
dc.contributor.authorGoswami, U.
dc.contributor.authorRojatkar, S.R.
dc.contributor.authorKhan, M.I.
dc.date.accessioned2008-07-22T06:51:37Z
dc.date.available2008-07-22T06:51:37Z
dc.date.issued2008
dc.identifier.citationBioorganic and Medicinal Chemistry Letters, Vol.18; 3963-3967p.
dc.identifier.urihttp://drs.nio.org/drs/handle/2264/1302
dc.description.abstractBioactivity guided fractions of cell-free hemolymph of bacterially challenged marine mussel, Perna viridis led to the isolation of a novel quaternary alkaloid 1, which was identified by its spectral data. The isolated molecule 1 has been found to be a potent serine protease inhibitor (SPI) showing IC sub(50) and K sub(i) values of 102.5 and 97.1-104.68 mu M, respectively. The E sub(t)/K sub(i) value of SPI is 6.3, whereas E sub(t)/K sub(m) value is 1.04. The Van't Hoff analysis showed that the value of K sub(i) decreases with increase in temperature, and the binding of the inhibitor is entropically driven.
dc.language.isoen
dc.publisherElsevier
dc.rightsCopyright [2008]. It is tried to respect the rights of the copyright holders to the best of the knowledge. If it is brought to our notice that the rights are violated then the item would be withdrawn.
dc.titleA serine protease inhibitor from hemolymph of green mussel, Perna viridis
dc.typeJournal Article


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