Two selective novel triterpene glycosides from sea cucumber, Telenata ananas: Inhibitors of chemokine receptor-5
Date
2002Author
Hegde, V.R.
Chan, T.-M.
Pu, H.
Gullo, V.P.
Patel, M.G.
Das, P.
Wagner, N.
Parameswaran, P.S.
Naik, C.G.
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The aqueous methanolic extract of a sea cucumber was found to contain two triterpene glycosides 1 and 2. The structures of 1 and 2 were established based on high-resolution NMR studies. Compounds 1 and 2 exhibited inhibitory activity (K sub(i)) of 30 and 5 mu M, respectively, in a chemokine receptor subtype 5 (CCR5) assay. Both compounds did not show any significant inhibition in a CXCR2 assay at 50 mu M, suggesting their selectivity for the CCR5 receptor
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