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    Two selective novel triterpene glycosides from sea cucumber, Telenata ananas: Inhibitors of chemokine receptor-5

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    Bioorg_Med_Chem_Lett_12_3203.pdf (99.68Kb)
    Date
    2002
    Author
    Hegde, V.R.
    Chan, T.-M.
    Pu, H.
    Gullo, V.P.
    Patel, M.G.
    Das, P.
    Wagner, N.
    Parameswaran, P.S.
    Naik, C.G.
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    Abstract
    The aqueous methanolic extract of a sea cucumber was found to contain two triterpene glycosides 1 and 2. The structures of 1 and 2 were established based on high-resolution NMR studies. Compounds 1 and 2 exhibited inhibitory activity (K sub(i)) of 30 and 5 mu M, respectively, in a chemokine receptor subtype 5 (CCR5) assay. Both compounds did not show any significant inhibition in a CXCR2 assay at 50 mu M, suggesting their selectivity for the CCR5 receptor
    URI
    http://drs.nio.org/drs/handle/2264/1344
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