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dc.contributor.authorHegde, V.R.
dc.contributor.authorChan, T.-M.
dc.contributor.authorPu, H.
dc.contributor.authorGullo, V.P.
dc.contributor.authorPatel, M.G.
dc.contributor.authorDas, P.
dc.contributor.authorWagner, N.
dc.contributor.authorParameswaran, P.S.
dc.contributor.authorNaik, C.G.
dc.date.accessioned2008-08-03T10:23:23Z
dc.date.available2008-08-03T10:23:23Z
dc.date.issued2002
dc.identifier.citationBioorganic Medicinal Chemistry Letters,: Vol. 12; 3203-3205p.
dc.identifier.urihttp://drs.nio.org/drs/handle/2264/1344
dc.description.abstractThe aqueous methanolic extract of a sea cucumber was found to contain two triterpene glycosides 1 and 2. The structures of 1 and 2 were established based on high-resolution NMR studies. Compounds 1 and 2 exhibited inhibitory activity (K sub(i)) of 30 and 5 mu M, respectively, in a chemokine receptor subtype 5 (CCR5) assay. Both compounds did not show any significant inhibition in a CXCR2 assay at 50 mu M, suggesting their selectivity for the CCR5 receptor
dc.language.isoen
dc.publisherPergamon
dc.rightsElsevier Science Ltd
dc.subjectchemical extraction
dc.subjectglycosides
dc.subjectbioactive compounds
dc.subjectchemoreception
dc.subjectinhibitors
dc.subjectTelenata ananas
dc.titleTwo selective novel triterpene glycosides from sea cucumber, Telenata ananas: Inhibitors of chemokine receptor-5
dc.typeJournal Article


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