dc.contributor.author | Hegde, V.R. | |
dc.contributor.author | Chan, T.-M. | |
dc.contributor.author | Pu, H. | |
dc.contributor.author | Gullo, V.P. | |
dc.contributor.author | Patel, M.G. | |
dc.contributor.author | Das, P. | |
dc.contributor.author | Wagner, N. | |
dc.contributor.author | Parameswaran, P.S. | |
dc.contributor.author | Naik, C.G. | |
dc.date.accessioned | 2008-08-03T10:23:23Z | |
dc.date.available | 2008-08-03T10:23:23Z | |
dc.date.issued | 2002 | |
dc.identifier.citation | Bioorganic Medicinal Chemistry Letters,: Vol. 12; 3203-3205p. | |
dc.identifier.uri | http://drs.nio.org/drs/handle/2264/1344 | |
dc.description.abstract | The aqueous methanolic extract of a sea cucumber was found to contain two triterpene glycosides 1 and 2. The structures of 1 and 2 were established based on high-resolution NMR studies. Compounds 1 and 2 exhibited inhibitory activity (K sub(i)) of 30 and 5 mu M, respectively, in a chemokine receptor subtype 5 (CCR5) assay. Both compounds did not show any significant inhibition in a CXCR2 assay at 50 mu M, suggesting their selectivity for the CCR5 receptor | |
dc.language.iso | en | |
dc.publisher | Pergamon | |
dc.rights | Elsevier Science Ltd | |
dc.subject | chemical extraction | |
dc.subject | glycosides | |
dc.subject | bioactive compounds | |
dc.subject | chemoreception | |
dc.subject | inhibitors | |
dc.subject | Telenata ananas | |
dc.title | Two selective novel triterpene glycosides from sea cucumber, Telenata ananas: Inhibitors of chemokine receptor-5 | |
dc.type | Journal Article | |