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    Antispasmodic action of 5-methyl benzoxazoline-2-one: A preliminary study

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    Indian_J_Pharmacol_29_327.pdf (225.8Kb)
    Date
    1997
    Author
    DeSouza, R.D.
    Bhandare, P.N.
    Fernandes, N.
    Wahidullah, S.
    DeSouza, L.
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    Abstract
    In the present study, compound (1) depressed both phases of the dose-response curve. The marked effect on 5-HT response cannot be attributed solely to an antimuscarinic action of the compound which was much less (66%) as compared to (88%) in the case of 5-HT. The varying inhibitory effect of the compound of different spasmogens acting via diverse mechanisms suggests that its locus of action may be at a post receptor site, at some step in the transduction pathway. Further work is needed to elucidate the exact mode of action of this compound
    URI
    http://drs.nio.org/drs/handle/2264/2013
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