dc.contributor.author | Parvatkar, R.R. | |
dc.contributor.author | DeSouza, C. | |
dc.contributor.author | Tripathi, A. | |
dc.contributor.author | Naik, C.G. | |
dc.date.accessioned | 2009-03-31T10:48:13Z | |
dc.date.available | 2009-03-31T10:48:13Z | |
dc.date.issued | 2009 | |
dc.identifier.citation | Phytochemistry, vol.70(1); 128-132 | |
dc.identifier.uri | http://drs.nio.org/drs/handle/2264/2611 | |
dc.description.abstract | Two aromatic butenolides, aspernolides A and B along with the known metabolites, butyrolactone I, terrein and physcion were isolated from the fermentation broth of a soft coral derived fungus Aspergillus terreus. The structures of these metabolites were assigned on the basis of detailed spectroscopic analysis. The absolute stereochemistry of aspernolides A (1) and B (2) was established by their preparation from the known butyrolactone I. Biogenetically aspernolides A and B must be derived from butyrolactone I, a well known specific inhibitor of cyclin dependent kinase (cdk) from A. terreus. When tested, aspernolide A exhibited mild cytotoxicity against cancer cell lines | |
dc.language.iso | en | |
dc.publisher | Elsevier | |
dc.rights | An edited version of this paper was published by Elsevier. Copyright [2009] Elsevier | |
dc.subject | Aspergillus terreus | |
dc.subject | Marine natural products | |
dc.subject | Butenolides | |
dc.subject | Aspernolides | |
dc.subject | Chemical extraction | |
dc.subject | Bioactive compounds | |
dc.title | Aspernolides A and B, butenolides from a marine-derived fungus Aspergillus terreus | |
dc.type | Journal Article | |