Show simple item record

dc.contributor.authorParvatkar, R.R.
dc.contributor.authorDeSouza, C.
dc.contributor.authorTripathi, A.
dc.contributor.authorNaik, C.G.
dc.date.accessioned2009-03-31T10:48:13Z
dc.date.available2009-03-31T10:48:13Z
dc.date.issued2009
dc.identifier.citationPhytochemistry, vol.70(1); 128-132
dc.identifier.urihttp://drs.nio.org/drs/handle/2264/2611
dc.description.abstractTwo aromatic butenolides, aspernolides A and B along with the known metabolites, butyrolactone I, terrein and physcion were isolated from the fermentation broth of a soft coral derived fungus Aspergillus terreus. The structures of these metabolites were assigned on the basis of detailed spectroscopic analysis. The absolute stereochemistry of aspernolides A (1) and B (2) was established by their preparation from the known butyrolactone I. Biogenetically aspernolides A and B must be derived from butyrolactone I, a well known specific inhibitor of cyclin dependent kinase (cdk) from A. terreus. When tested, aspernolide A exhibited mild cytotoxicity against cancer cell lines
dc.language.isoen
dc.publisherElsevier
dc.rightsAn edited version of this paper was published by Elsevier. Copyright [2009] Elsevier
dc.subjectAspergillus terreus
dc.subjectMarine natural products
dc.subjectButenolides
dc.subjectAspernolides
dc.subjectChemical extraction
dc.subjectBioactive compounds
dc.titleAspernolides A and B, butenolides from a marine-derived fungus Aspergillus terreus
dc.typeJournal Article


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record