Tandem Wittig-ene reaction approach to kainic acid

dc.contributor.author	Majik, M.S.
dc.contributor.author	Parameswaran, P.S.
dc.contributor.author	Tilve, S.G.
dc.date.accessioned	2009-12-21T11:52:05Z
dc.date.available	2009-12-21T11:52:05Z
dc.date.issued	2009
dc.identifier.citation	The Journal of Organic Chemistry, vol.74(9); 3591-3594
dc.identifier.uri	http://drs.nio.org/drs/handle/2264/3498
dc.description.abstract	The first example of a tandem Wittig-intramolecular ene reaction approach and its application toward the synthesis of kainic acid is reported. The synthetic pathway involves conversion of prenyl bromide into phosphorane 3, followed by one-pot Wittig olefination and an ene reaction with glyoxalic acid to give the cis fused pyrrolidine skeleton of kainic acid.
dc.language.iso	en
dc.publisher	American Chemical Society
dc.rights	© 2009 American Chemical Society. All efforts have been made to respect the copyright to the best of our knowledge. Inadvertent omissions, if brought to our notice, stand for correction and withdrawal of document from this repository.
dc.subject	bioactive compounds
dc.subject	amino acids
dc.subject	kainic acid
dc.subject	Tandem Wittig-ene reaction
dc.title	Tandem Wittig-ene reaction approach to kainic acid
dc.type	Journal Article