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    Isolation and Identification of Tyrosinase Inhibitors from Marine Algae Enteromorpha sp

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    Date
    2021
    Author
    Rodrigues, L.
    Tilvi, S.
    Fernandes, M.S.
    Harmalkar, S.S.
    Tilvi, S.
    Majik, M.S.
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    Abstract
    The extract of marine green algae Enteromorpha sp. was evaluated in vitro for inhibitory activity against mushroom tyrosinase enzyme. The principle active agents i.e. coumarin; 4-hydroxycoumarin (1) and two sterols; ergosta-5,7,22-trien-3?-ol (2) and ergosterol peroxide (3) were isolated for the first time, from a crude methanol extract of Enteromorpha sp. showing anti-tyrosinase activity. Their structures were elucidated by IR, extensive NMR spectroscopy, LC-ESI-MS, Single crystal X-ray diffraction techniques. Thus, Enteromorpha sp. can be an alternative edible anti-tyrosinase agent.
    URI
    https://doi.org/http://dx.doi.org/10.2174/1570178617999200721011816
    https://drs-beta.nio.org/drs/handle/2264/8604
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